Pharmacological Mechanisms of Action of Bacillus coagulans
Pharmacological Action
Bacillus coagulans is not an inherent microorganism in the intestine. Its physiological function in the intestine is achieved through the secretion of various beneficial substances and synergistic effects with other probiotics in the intestine, rather than the action of any specific substance. After oral administration, Bacillus coagulans is activated by gastric juice, causing the spore coat to expand, the spore shape to increase, water content to increase, and metabolism to accelerate. When Bacillus coagulans enters the duodenum, its spores germinate into nutrient cells. After entering the small intestine, nutrient cells begin to grow and reproduce, reproducing for about 30 minutes per generation. Bacillus coagulans are facultative anaerobic bacteria that consume free oxygen upon entering the intestine for intestinal reproduction. This promotes the growth of anaerobic microorganisms such as lactobacilli and bifidobacteria, thereby regulating the balance of gut microbiota, enhancing the body's immunity and disease resistance, and reducing the occurrence of intestinal diseases. During the process of intestinal reproduction, Bacillus coagulans also secrete amylase and protease, promoting the digestion and absorption of nutrients by the body; The B vitamins, amino acids, short chain fatty acids, and other substances produced by it can increase the peristalsis speed of the small intestine, thereby improving the digestive function of the intestine. In addition, after settling in the intestine, Bacillus coagulans can also produce a large amount of antibacterial substances such as Coagulin and L (+) lactic acid, which can inhibit harmful bacteria. Therefore, it has a certain therapeutic effect on gastrointestinal inflammation.
Functions of Bacillus coagulans in Animal Feed
It is used mainly as a probiotic feed additive to treat acute and chronic diarrhea, chronic constipation, abdominal distension, and indigestion caused by dysbiosis of the gut microbiota.
Features
1. Effectively inhibit the growth of harmful bacteria, improve the intestinal microbiota environment, promote intestinal development, and enhance intestinal function.
2. Improve feed quality, promote digestion and absorption of feed, and reduce feed to weight ratio.
3. Effectively improve the dysbiosis of the microbiota caused by stress and allergic reactions in weaned piglets.
4. No toxic side effects, safe to use, and can reduce harmful gases such as ammonia and hydrogen sulfide in the environment, improving the breeding environment.
